Earlier Nutrient Fortification of Breastmilk Fed LBW Infants Improves Jaundice Related Outcomes
| Autor: | Xiao Wei Ma, Wei Qi Fan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Gastroenterology jaundice chemistry.chemical_compound 0302 clinical medicine Weight loss Birth Weight Medicine 030212 general & internal medicine LBW Nutrition and Dietetics Anthropometry Jaundice Infant Formula Treatment Outcome Food Fortified Female medicine.symptom lcsh:Nutrition. Foods and food supply Nutritive Value Infant Premature Adult medicine.medical_specialty hyperbilirubinemia Bilirubin Birth weight fortification lcsh:TX341-641 Article Excretion Young Adult 03 medical and health sciences 030225 pediatrics Internal medicine Humans Retrospective Studies Milk Human business.industry Infant Newborn Infant Infant Low Birth Weight Phototherapy Low birth weight chemistry Infant formula Dietary Supplements preterm business Food Science |
| Zdroj: | Nutrients Volume 12 Issue 7 Nutrients, Vol 12, Iss 2116, p 2116 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12072116 |
| Popis: | This study aimed to evaluate jaundice outcomes of low-birthweight premature infants commenced on earlier versus later nutrient supplementation (80 mL/kg/day vs. 160 mL/kg/day total fluid intake, F80 vs. F160). Demographics, feeding regimens, and clinical outcomes data were collected. Infant and maternal characteristics were similar. Earlier nutrient supplementation was associated with multiple improved jaundice outcomes: total (TSBR), unconjugated and conjugated (CSBR) serum bilirubin values (196 ± 46 vs. 228 ± 52, 184 ± 44 vs. 212 ± 50, 12 ± 4 vs. 16 ± 5, respectively, all p < 0.001) phototherapy (39% vs. 64%, p < 0.0001). % CSBR/TSBR ratio was similar between groups. For those on phototherapy, duration and median irradiance were similar. F80 infants experienced reduced: feeding intolerance (26.0% vs. 45.2%, p = 0.007) length of stay (16.0 ± 0.64 vs. 18.8 ± 0.74 days, p = 0.03), maximum weight loss as % birth weight (5% vs. 6%, p = 0.03) decrease in weight Z-score at 10 days (&minus 0.70 ± 0.03 vs. &minus 0.79 ± 0.03, p = 0.01). F80 infants regained birthweight earlier (10.0 ± 0.3 days vs. 11.5 ± 0.3 days, p < 0.0001) and had no differences in adverse clinical outcomes. We speculate that earlier nutrient supplementation improved jaundice outcomes due to enhanced excretion/elimination of bilirubin. |
| Databáze: | OpenAIRE |
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