Polysaccharide-based nanocomposites for biomedical applications: a critical review

Autor: Hanieh Shokrani, Amirhossein Shokrani, S. Mohammad Sajadi, Mohsen Khodadadi Yazdi, Farzad Seidi, Maryam Jouyandeh, Payam Zarrintaj, Saptarshi Kar, Seok-Jhin Kim, Tairong Kuang, Navid Rabiee, Alexander Hejna, Mohammad Reza Saeb, Seeram Ramakrishna
Rok vydání: 2022
Předmět:
Zdroj: Nanoscale Horizons. 7:1136-1160
ISSN: 2055-6764
2055-6756
Popis: Polysaccharides (PSA) have taken specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties are known as the main drawback of PSA, which highlights the need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use, they have not been reviewed. Herein, we critically reviewed the application of NPSA by categorizing them into generic and advanced application realms. First, the application of NPSA as drug and gene delivery systems, along with their role in the field as an antibacterial platform and hemostasis agent is discussed. Then, applications of NPSA for skin, bone, nerve, and cartilage tissue engineering are highlighted, followed by cell encapsulation and more critically cancer diagnosis and treatment potentials. In particular, three features of investigations are devoted to cancer therapy
Databáze: OpenAIRE