3D printing of PVA capsular devices for modified drug delivery: design and in vitro dissolution studies

Autor:	Ivana María Cotabarren, Loreana Gallo
Rok vydání:	2020
Předmět:	Materials science In vitro dissolution Pharmaceutical Science 3D printing 02 engineering and technology 030226 pharmacology & pharmacy law.invention 03 medical and health sciences 0302 clinical medicine law Drug Discovery Technology Pharmaceutical Immediate release Dissolution Pharmacology Fused deposition modeling business.industry Manufacturing process Organic Chemistry 021001 nanoscience & nanotechnology Drug Liberation Pharmaceutical Preparations Solubility Compounding Printing Three-Dimensional Drug delivery 0210 nano-technology business Biomedical engineering
Zdroj:	Drug Development and Industrial Pharmacy. 46:1416-1426
ISSN:	1520-5762 0363-9045
Popis:	The fabrication through FDM 3D printing of hollow systems intended for oral drug delivery constitutes an attractive technology to change personalized medications in the compounding pharmacy. In this sense, this work studied the design and 3D printing of one compartment capsular devices filled of drugs that could require a delayed release mechanism. The optimization of printing parameters such as material flow rate and printing speed by means of simple gcode modifications, resulted critical to allow the production of PVA capsular devices in a single manufacturing process. In addition, the disintegration and dissolution studies of the obtained capsular device confirmed the existence of a delayed drug release compared to commercial hard-gelatin capsules. Furthermore, the use of sinkers in the dissolution tests resulted in similar dissolution profiles regardless the rotation speed. Finally, Gompertz and Weibull equations were the kinetic models that best fitted the experimental data corresponding to immediate release with lag time type profiles. Overall, this work provides insights to understand the effect of the printing parameters on the production of PVA capsular devices and suggests a simple design and single manufacturing process that can be adopted in the future compounding pharmacy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c58a2d3bea3a126bc0e4e1a8bd3f185 https://doi.org/10.1080/03639045.2020.1791166 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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