CD4+T Cell Surface CCR5 Density as a Determining Factor of Virus Load in Persons Infected with Human Immunodeficiency Virus Type 1
| Autor: | Monsef Benkirane, Pascal André, Jean-François Eliaou, Michel Segondy, Jacques Clot, Odile Avinens, Brigitte Réant, Pierre Portales, Jacques Reynes, Vincent Baillat, Guilhem Couderc, Pierre Corbeau |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Chemokine Receptors CCR5 Chemokine receptor CCR5 viruses Cell Virus In vivo medicine Humans Immunology and Allergy Viremia Receptor Acquired Immunodeficiency Syndrome biology virus diseases HLA-DR Antigens Virology Infectious Diseases medicine.anatomical_structure Immunology HIV-1 biology.protein Cell activation Viral load |
| Zdroj: | The Journal of Infectious Diseases. 181:927-932 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/315315 |
| Popis: | The intensity of expression of the chemokine receptor CCR5 is involved in in vitro cell infectability by human immunodeficiency virus (HIV)-1 R5 isolates. Because CCR5 expression varies among individuals, the hypothesis that this expression could determine virus load in HIV-1-infected persons was tested. The mean number of CCR5 molecules per cell was measured on peripheral blood CD4+ T lymphocytes (CCR5 density) from HIV-1-infected, asymptomatic, nontreated adults. There was a strong correlation between HIV RNA plasma level and CCR5 density (P=.009) that was independent of cell activation and was not due to an HIV-induced CCR5 up-regulation. These data are compatible with the hypothesis that CCR5 density is a key factor governing cell infectability and in vivo virus production and explain the protective effect of the Delta32CCR5 deletion, which results in low CCR5 expression. CCR5 density might be of critical predictive value in HIV infection. |
| Databáze: | OpenAIRE |
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