RUNX3 Polymorphisms Affect the Risk of Ankylosing Spondylitis
| Autor: | Wen-Hao Hu, Yan Wang, Ligong Fu, Hua-Wei Liu, Jianjin Zhu, Jing Li, Deng Jiuzheng, Dong Hu, Dawei He, Song-Hua Xiao, Kai Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype 030204 cardiovascular system & hematology Logistic regression Gastroenterology Polymerase Chain Reaction Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Lab/In Vitro Research Risk Factors Internal medicine Ethnicity Odds Ratio Medicine Humans Protein Interaction Domains and Motifs Spondylitis Ankylosing Genetic Predisposition to Disease Allele Genotyping Polymorphism Single-Stranded Conformational Alleles Ankylosing spondylitis business.industry General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Carriage Core Binding Factor Alpha 3 Subunit 030220 oncology & carcinogenesis Case-Control Studies Female business Polymorphism Restriction Fragment Length |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND We aimed to assess the potential association of runt-related transcription factor 3 (RUNX3) gene variants with ankylosing spondylitis (AS) susceptibility among Chinese Han people. MATERIAL AND METHODS Genotyping for RUNX3 variants was accomplished through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 115 AS patients and 102 healthy controls. Genotypes distributions of the polymorphisms in controls was assessed for their deviation from Hardy-Weinberg equilibrium (HWE). Moreover, odds ratio (OR) with 95% confidence interval (95%CI) was achieved using chi-square analysis to evaluate AS risk related to RUNX3 polymorphisms. Additionally, logistic regression analysis produced adjusted OR values. RESULTS Genotypes distribution of rs760805 and rs11249206 polymorphisms conformed to HWE in the control group (P>0.05). TT genotype of rs760805 appeared more frequently among AS cases than in controls (P=0.033), indicating its significant association with increased risk of AS onset (OR=2.309, 95%CI=1.069-4.892). The carriage of T allele in rs760805 also heightened AS incidence, in comparison to A allele (OR=1.578, 95%CI=1.075-2.316, P=0.020). Moreover, the carriage of AT+TT genotype in rs760805 and TT genotype in rs11249206 obviously increased risk of AS onset (OR=2.585, 95%CI=1.062-6.288). CONCLUSIONS RUNX3 rs760805 polymorphism can contribute to AS incidence in Chinese Han people. The interaction of the 2 polymorphisms may be a risk factor for AS. |
| Databáze: | OpenAIRE |
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