Targeting proximal T cell receptor signaling in transplantation
| Autor: | Majed M. Hamawy |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Graft Rejection
Transplantation Transcription Genetic Tcr signaling Mechanism (biology) T-cell receptor T cell receptor signaling Receptors Antigen T-Cell hemic and immune systems chemical and pharmacologic phenomena T lymphocyte Biology Models Biological Cell biology Antigens CD Transplantation Immunology Immunology Humans Signal transduction Signalling pathways Signal Transduction |
| Zdroj: | Transplantation. 75:1921-1927 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/01.tp.0000070168.42915.47 |
| Popis: | In the past two decades, an immense amount of information has been generated on the mechanism of T cell receptor (TCR) signaling (also called signal 1). This overview describes the major signalling pathways in the TCR signal transduction cascade and focuses on proximal events in TCR signaling. The review also discusses some of the strategies that target proximal TCR signaling, which are used for preventing graft rejection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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