Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee
| Autor: | Julian Parkhill, Astrid Lewin, Sonja Metzger, Sebastien Gagneux, Julia Feldman, Andreas Nitsche, Kerstin Maetz-Rennsing, Pjotr Wojtek Dabrowski, Christophe Boesch, Fabian H. Leendertz, Emmanuel Couacy-Hymann, Mireia Coscolla, Iñaki Comas, Aleksandar Radonić, Stefan Niemann, Sébastien Calvignac-Spencer |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Tuberculosis Pan troglodytes Epidemiology MTBC lcsh:Medicine nonhuman primate Polymorphism Single Nucleotide lcsh:Infectious and parasitic diseases West africa Mycobacterium tuberculosis 03 medical and health sciences Phylogenetics medicine M. tuberculosis Animals lcsh:RC109-216 mammals Animal species bacteria Phylogeny 030304 developmental biology Genetics 0303 health sciences Genetic diversity biology 030306 microbiology Research lcsh:R Sequence Analysis DNA biology.organism_classification medicine.disease infection 3. Good health tuberculosis and other mycobacteria zoonoses Ape Diseases Infectious Diseases TB Mycobacterium tuberculosis complex tuberculosis Infectious disease (medical specialty) wild chimpanzee Africa Female Genome Bacterial lineage |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 19, Iss 6, Pp 969-976 (2013) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Tuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild animal species. We report an M. tuberculosis strain isolated from a wild chimpanzee in Côte d’Ivoire that was shown by comparative genomic and phylogenomic analyses to belong to a new lineage of MTBC, closer to the human-associated lineage 6 (also known as M. africanum West Africa 2) than to the other classical animal-associated MTBC strains. These results show that the general view of the genetic diversity of MTBC is limited and support the possibility that other MTBC variants exist, particularly in wild mammals in Africa. Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease. |
| Databáze: | OpenAIRE |
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