The ABL kinase inhibitor imatinib causes phenotypic changes and lethality in adult Schistosoma japonicum
| Autor: | Christoph G. Grevelding, Xuesong Li, Min Hu, Junlong Zhao, Lu Liu, Lu Zhao, Tao Zhu, Rui Fang, Mudassar Niaz Mughal, Simone Haeberlein, Yanqin Zhou |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Gastropoda 030231 tropical medicine Drug Resistance Schistosomiasis Drug resistance Biology Schistosoma japonicum 030308 mycology & parasitology Mice Schistosomicides 03 medical and health sciences 0302 clinical medicine Parasitic Sensitivity Tests hemic and lymphatic diseases parasitic diseases medicine Animals Humans Amino Acid Sequence Protein Kinase Inhibitors neoplasms 0303 health sciences ABL General Veterinary Gastrodermis Imatinib Schistosoma mansoni General Medicine biology.organism_classification medicine.disease Infectious Diseases Imatinib mesylate Schistosomiasis japonica Insect Science Immunology Imatinib Mesylate Female Parasitology Sequence Alignment medicine.drug |
| Zdroj: | Parasitology Research. 118:881-890 |
| ISSN: | 1432-1955 0932-0113 |
| Popis: | Schistosomiasis caused by different species of schistosome parasites is one of the most debilitating helminthic diseases of humans worldwide. For decades, chemotherapy is the main method of controlling schistosomiasis. However, the fear of drug resistance has motivated the search for alternatives. It has been demonstrated that the ABL kinase inhibitor imatinib affected the development and survival of Schistosoma mansoni in vitro; however, there is still lack of information on whether imatinib also affects other schistosome species such as Schistosoma japonicum. In the present study, the anti-schistosomal potency of imatinib on adult S. japonicum was investigated in vitro, and the results showed that imatinib had a significant impact on various physiological processes of S. japonicum adult worms. Besides its negative effects on worm motility, pairing stability, and gonad development, imatinib caused pathological changes in the gastrodermis as well as the death of the parasite. Our findings suggest that imatinib is an intriguing candidate for further development as an option to fight S. japonicum. |
| Databáze: | OpenAIRE |
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