Rapid investigation of BA.4/BA.5 cases in France
| Autor: | Alain-Claude, Kouamen, Helena, Da Cruz, Mohamed, Hamidouche, Anais, Lamy, Anna, Lloyd, Javier, Castro Alvarez, Mathilde, Roussel, Laurence, Josset, Vincent, Enouf, Charlotte, Felici, Georges, Dos Santos, Justine, Schaeffer, Anna, Maisa, Anne, Lavergne |
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| Přispěvatelé: | Direction santé environnement travail - Santé Publique France, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Santé publique France Bourgogne-Franche-Comté, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité), Santé publique France Nouvelle-Aquitaine [Bordeaux], Laboratoire CERBA [Saint Ouen l'Aumône], Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Pasteur International Bioresources network (PIBNet), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]-Université de Montpellier (UM) |
| Rok vydání: | 2022 |
| Předmět: |
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
MESH: Humans MESH: Middle Aged Time Factors Omicron SARS-CoV-2 MESH: Time Factors Public Health Environmental and Occupational Health MESH: Hospitalization Middle Aged Hospitalization Cough MESH: Risk Factors [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Risk Factors Surveys and Questionnaires Symptoms MESH: Cough Humans [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Variant MESH: Surveys and Questionnaires BA.4 BA.5 |
| Zdroj: | Frontiers in Public Health Frontiers in Public Health, 2022, 10, pp.100663. ⟨10.3389/fpubh.2022.1006631⟩ |
| ISSN: | 2296-2565 |
| DOI: | 10.3389/fpubh.2022.1006631⟩ |
| Popis: | AimWe aimed to describe the characteristics of individuals infected by BA.4 or BA.5 in France in comparison to BA.1, and analyze the factors associated with hospitalization among BA.4 and BA.5 cases.MethodsA standardized questionnaire was used to collect information on confirmed and probable Omicron cases. Hospitalization risk factors among BA.4/BA.5 cases were analyzed using Poisson regression. Variables with a p-value below 0.2 in the univariate analysis and a priori confounders were included in the multivariable regression model.ResultsThe median age of the 301 cases investigated was 47 years and 97% of cases were symptomatic. The most common clinical signs were asthenia/fatigue (75.7%), cough (58.3%), fever (58.3%), headache (52.1%) and rhinorrhea (50.7%). Twelve cases were hospitalized, and 27.1% reported risk factors. No admissions to intensive care and no deaths were reported. Vaccination status was available for 292 cases, 20.9% were unvaccinated, 1.4% had received one dose, 38.3% two doses and 39.4% three doses. Cases presenting at least one risk factor were almost seventeen times more likely to be hospitalized than those with no risk factors (aRR = 16.72 [95% CI2.59–326.86]).ConclusionDespite the longer duration of and the differences in symptoms and their possible immune escape, BA.4/BA.5 Omicron sub-lineages globally showed no severe clinical presentation. The presence of at least one risk factor for severe disease significantly increased the risk of hospitalization for those infected with BA.4 or BA.5. |
| Databáze: | OpenAIRE |
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