Drug-related hospitalization at a tertiary teaching center in Lebanon: Incidence, associations, and relation to self-medicating behavior*
| Autor: | Rania Richani, Lama Bahlawan, Ali Melhem, Samia Badr, Ghinwa Hassan, Ramzi Khalil, Fadi Younes, Joumana S. Yeretzian, Mustafa Khogali, Tsoline Khogaoghlanian, Stella Major, Ramzi Sabra |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Drug Pediatrics medicine.medical_specialty Adolescent Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Self Medication Logistic regression law.invention Sex Factors law medicine Humans Pharmacology (medical) Medical history Lebanon Risk factor Child Hospitals Teaching Socioeconomic status media_common Pharmacology Clinical pharmacology business.industry Incidence Incidence (epidemiology) Middle Aged medicine.disease Hospitalization Logistic Models Socioeconomic Factors Child Preschool Female business Adverse drug reaction |
| Zdroj: | Clinical Pharmacology & Therapeutics. 64:450-461 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1016/s0009-9236(98)90076-5 |
| Popis: | Objective In Lebanon there is very limited restriction on drug use. Accordingly, self-medication is highly prevalent. This study examined the influence of these factors on the development of drug-related illnesses that lead to hospitalization. Methods Patients admitted to the medical and pediatric wards of a tertiary teaching center in Beirut, Lebanon, over a period of 6 months were interviewed and their charts were reviewed. Admissions attributable to adverse drug reactions or therapeutic failures were identified and characterized with respect to demographic factors, medical history, drug intake, and self-medicating behavior. The influence of these variables on the development of drug-related illnesses was examined by logistic regression. Results Of 1745 adults and 457 children, there were 177 (10.2%) and 36 (7.9%) drug-related illnesses, respectively. Adverse drug reactions accounted for 7.0% and 5.7% and therapeutic failures for 3.2% and 2.2% of adult and pediatric admissions, respectively. Self-medication was commonly practiced (52.6% of adults and 41.6% of children). Logistic regression analysis revealed that female sex increased the risk of adverse drug reaction in adults, whereas self-medication decreased the risk. In children, the risk of adverse drug reaction was increased in lower socioeconomic groups, whereas the risk of therapeutic failure was increased by a positive history of atopy or drug reaction. Conclusions These results provide the first detailed analysis of the problem of drug-related illnesses in a developing country and identify a number of related or risk factors. Despite the lack of regulation of drug dispensing and the unchecked access to drugs in Lebanon, the incidence of drug-related illnesses is not different from that in Western nations. This finding may have relevance to policies of drug regulation in other countries. Clinical Pharmacology & Therapeutics (1998) 64, 450–461; doi |
| Databáze: | OpenAIRE |
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