Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study
| Autor: | Roel Willemze, Pauline Meij, J.H. Frederik Falkenburg, Linda Cox, Rian Bongaerts, Erik W.A. Marijt, Amon R. Wafelman, Inge Jedema, Menno A. W. G. van der Hoorn |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
minor histocompatibility antigen medicine.medical_specialty Adoptive cell transfer T cell medicine.medical_treatment Pilot Projects Hematopoietic stem cell transplantation CD8-Positive T-Lymphocytes Minor Histocompatibility Antigens Recurrence allogeneic stem cell transplantation HA-1 Internal medicine medicine Humans Transplantation Homologous adoptive cellular immunotherapy Leukemia business.industry Hematopoietic Stem Cell Transplantation Hematology medicine.disease Adoptive Transfer Transplantation Treatment Outcome medicine.anatomical_structure CTL Immunology Bone marrow Original Articles and Brief Reports Stem cell business Oligopeptides CD8 |
| Zdroj: | Haematologica, 97(8), 1205-1208 |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2011.053371 |
| Popis: | Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells to patients with relapsed leukemia after allogeneic stem cell transplantation. The in vitro generation of clinical grade HA-1-specific T-cell lines from HA-1 negative donors was seen to be feasible and 3 patients were treated with HA-1-specific T-cell lines. No toxicity after infusion was observed. Although in one patient, during a period of stable disease, HA-1-specific T cells could be detected in the peripheral blood and bone marrow, these patients had no clear clinical response. |
| Databáze: | OpenAIRE |
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