Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse
| Autor: | E. Procaccini, Alberto Signore, E. A. M. Gale, J. Krug, Paolo Pozzilli, P. E. Beales, A. J. K. Williams, S. Xu |
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| Rok vydání: | 1993 |
| Předmět: |
Blood Glucose
Aging medicine.medical_specialty Tolbutamide Endocrinology Diabetes and Metabolism medicine.medical_treatment Impaired glucose tolerance Islets of Langerhans Mice Mice Inbred NOD Internal medicine Diabetes mellitus Internal Medicine medicine Diazoxide Animals Insulin Cumulative incidence business.industry Incidence (epidemiology) Pancreatic Diseases medicine.disease Diabetes Mellitus Type 1 Endocrinology Female business Insulitis medicine.drug |
| Zdroj: | Diabetologia. 36:487-492 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | The functional state of beta cells may influence the rate of their destruction in Type 1 (insulin-dependent) diabetes mellitus. We examined the effect of diazoxide, which inhibits insulin secretion, or tolbutamide, which stimulates insulin secretion, upon the incidence of diabetes in the non-obese-diabetic (NOD) mouse. Female mice were treated from 3–30 weeks of age with diet containing diazoxide 250 mg·kg−1 or tolbutamide 125 mg·kg−1. The cumulative incidence of diabetes at 35 weeks was similar in the diazoxide (16 of 24) and control (18 of 24) groups, but reduced in the tolbutamide group (10 of 23,p |
| Databáze: | OpenAIRE |
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