In vitro Glucoregulation of Prolactin Secretion
| Autor: | Ameae M. Walker, Carol Langford, Junko Kadowaki |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
endocrine system
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Radioimmunoassay Stimulation Deoxyglucose In Vitro Techniques Hypoglycemia Biology Rats Sprague-Dawley Prolactin cell Cellular and Molecular Neuroscience Endocrinology Anterior pituitary Pituitary Gland Anterior Internal medicine medicine Animals Insulin Secretion Cells Cultured Dose-Response Relationship Drug Endocrine and Autonomic Systems medicine.disease Prolactin Rats Glucose medicine.anatomical_structure Female Blood sugar regulation hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroendocrinology. 56:838-844 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000126314 |
| Popis: | In this study we have examined the direct glucoregulation of prolactin secretion from normal anterior pituitary cells in vitro and have found that changes in medium glucose concentration regulate the amount of prolactin released. Nature and/or degree of this response to glucose was influenced by some effect, long-lived in vitro, which was correlatable to serum insulin levels. When the cells were derived from animals with mean low-normal serum insulin levels, there was a stimulation of prolactin secretion by hypoglycemia, the response was rapid, transient, dose-dependent, and could be duplicated by 2-deoxyglucose. When the cells were derived from animals with a higher mean serum insulin level, the prolactin secretion from the cells was slowly, adversely affected by hypoglycemia. Conversely, elevated glucose caused a depression in prolactin secretion in the first group and a stimulation of prolactin secretion in the second. We conclude (1) that modulation of glucose levels in vitro regulates prolactin release from pituitary mammotrophs and (2) that this glucose regulation of prolactin release is in turn coregulated with or regulated by insulin. |
| Databáze: | OpenAIRE |
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