Localization of the human catalase and apolipoprotein A-I genes to chromosome 11
| Autor: | W.T. Schroeder, G.F. Saunders |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Genetic Markers
Acatalasemia Apolipoprotein B Genetic Linkage Biology Human disease Gene mapping Genetics Humans Molecular Biology Gene Apolipoproteins A Genetics (clinical) chemistry.chemical_classification Apolipoprotein A-I Chromosomes Human Pair 11 Chromosome Mapping Nucleic Acid Hybridization Chromosome DNA Catalase Molecular biology Chromosome Banding Enzyme chemistry biology.protein |
| Zdroj: | Cytogenetic and Genome Research. 44:231-233 |
| ISSN: | 1424-859X 1424-8581 |
| DOI: | 10.1159/000132377 |
| Popis: | Studies of the catalase and apolipoprotein A-I genes are pertinent to the understanding of human disease. Not only are these genes involved in acatalasemia and atherosclerosis, respectively, but they are also important gene markers for chromosome 11, deletions of which are involved in the development of Wilms tumor. We have used in situ hybridization to localize these genes to specific bands on chromosome 11. Hybridization with a catalase cDNA yielded a significant number of cells (38%) exhibiting label at band 1 lpl3. A high percentage of metaphase cells (50%) hybridized with a human genomic fragment containing the gene for apolipoprotein A-I displayed labeling at 11q13. |
| Databáze: | OpenAIRE |
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