Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: a meta-analysis
| Autor: | Tsantes, Argirio E., Nikolopoulos, Georgios K., Bagos, Pantelis G., Tsiara, Chrissa G., Kapsimali, Violetta, Travlou, Anthi S., Vaiopoulos, G. |
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| Přispěvatelé: | Nikolopoulos, Georgios K.[0000-0002-3307-0246], Bagos, Pantelis G. [0000-0003-4935-2325] |
| Rok vydání: | 2007 |
| Předmět: |
Male
Protein function Plasminogen activator inhibitor type-1 Cohort Studies chemistry.chemical_compound Gene Frequency Risk Factors Medicine Genetic epidemiology Stroke Priority journal Ischemic stroke Hematology General Medicine Plasminogen activator inhibitor-1 Cohort studies Female Brain infarction Human Cohort study Brain Infarction medicine.medical_specialty Genotype Case-control studies Article Plasminogen Activators Genetic Gene insertion Cerebrovascular accident Internal medicine 4g/5g polymorphism Humans Polymorphism Risk factor Plasminogen activator inhibitor 1 Genetic risk Genetic polymorphism Polymorphism Genetic Gene deletion Plasminogen activators business.industry Case-control study Odds ratio medicine.disease Gene frequency Confidence interval Surgery Meta-analysis Risk factors chemistry Relative risk Case-Control Studies business |
| Zdroj: | Blood Coagulation and Fibrinolysis |
| ISSN: | 0957-5235 |
| Popis: | This study investigated the hypothesis that the insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor type-1 gene affects the risk for ischemic stroke, since results concerning this association have been controversial. We therefore performed a meta-analysis of published data regarding this issue. A comprehensive electronic search was carried out until January 2006. The analysis was performed using random-effects models and meta-regression. Eighteen eligible studies were retrieved (15 case-control studies and three cohort studies). The case-control studies included 3104 cases and 4870 control individuals concerning the contrast of 4G/4G versus remaining genotypes. The 4G pooled allele frequencies in cases and controls were 54.21 and 54.75%, respectively. Overall, the per-allele odds ratio of the 4G allele was 0.98 (95% confidence interval, 0.858-1.121). Regarding genotypes, we derived nonsignificant odds ratios in all contrasts. The subanalysis including the three studies with a prospective design in the 4G/4G versus 5G/5G contrast derived a significant result (relative risk, 0.523; 95% confidence interval, 0.353-0.775), but the estimated effect size was insignificant when cohort and case-control studies were analyzed together (relative risk, 0.848; 95% confidence interval, 0.662-1.087). We failed to demonstrate a significant association between the 4G/5G polymorphism and ischemic stroke under basal conditions. Determination of plasminogen activator inhibitor type-1 function seems of much higher clinical value than determination of the 4G/5G polymorphism. The effect of this genotype on risk of ischemic stroke in acute stressful diseases and the role of cohort studies in genetic epidemiology, however, warrant further investigation. © 2007 Lippincott Williams & Wilkins, Inc. 18 5 497 504 |
| Databáze: | OpenAIRE |
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