Conductive all-carbon nanotube layers: Results on attractive physicochemical, anti-bacterial, anticancer and biocompatibility properties
| Autor: | Marek Nocuń, Luke D. Geoffrion, Aleksandra Benko, Sebastian Wilk, Marta Bińczak, Grégory Guisbiers, Elżbieta Menaszek, David Medina-Cruz, Thomas J. Webster, Andrzej Kotarba, Joanna Duch, Tadeusz Popiela |
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| Rok vydání: | 2020 |
| Předmět: |
Nanotube
Materials science Biocompatibility chemistry.chemical_element Bioengineering 02 engineering and technology Carbon nanotube 010402 general chemistry 01 natural sciences law.invention Biomaterials law Animals Humans Cytotoxicity chemistry.chemical_classification Reactive oxygen species biology Bacteria Nanotubes Carbon Electric Conductivity Fibroblasts 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Anti-Bacterial Agents chemistry Mechanics of Materials Cancer cell Biophysics 0210 nano-technology Carbon |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 120 |
| ISSN: | 1873-0191 |
| Popis: | Physicochemical, electrochemical and biological performance of 4 types of all-carbon nanotube layers was studied. Higher oxidation state of carbon was responsible for micro-scaled uniformity of the layers and excellent electrical conductivity, while nitrogen containing functional groups yielded materials with anisotropy similar to natural tissues and reduced work function. All materials were cytocompatible with mammalian fibroblasts (viability80%, cytotoxicity3% at day 7) and human dermal fibroblast (viability of cells70% at day 1), while reducing bacterial and cancer cells proliferation without adding any drug. After 8 h culture, a ~50% depletion in the number of Gram-positive bacteria was observed on materials with lower work function, while Gram-negative bacteria were more sensitive towards carbon coordination number and presence of nitrogen atoms (cell depletion of up to 48% on amidized carbon nanotubes). After 1-day culture,80% reduction in the melanoma cells number, connected with enhanced production of reactive oxygen species (ROS) was observed. All-carbon nanotube layers decreased bacteria and cancer cell functions without negatively influencing mammalian cells nor using drugs and we believe that this can be explained by various sensitivity of the tested cells towards exogenous ROS overproduction. As the concerns over implant-related infections as well as rates of antibiotic-resistant bacteria and chemotherapeutic-resistant cancer cells are growing, such materials should pave the way for a wide range of biomedical applications. |
| Databáze: | OpenAIRE |
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