siRNA-Conjugated Nanoparticles to Treat Ovarian Cancer
| Autor: | Michael Chen, Eun Ji Chung, Christopher Halbur, Niharika Choudhury, Jun Hyuk Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Small interfering RNA
Genetic enhancement Drug Evaluation Preclinical Early detection Antineoplastic Agents 03 medical and health sciences 0302 clinical medicine RNA interference medicine Humans Gene Silencing Molecular Targeted Therapy RNA Small Interfering 030304 developmental biology Ovarian Neoplasms 0303 health sciences Biological Products Drug Carriers business.industry Cancer medicine.disease Biocompatible material Computer Science Applications Medical Laboratory Technology 030220 oncology & carcinogenesis Gene Knockdown Techniques Ovarian cancer cells Cancer research Nanoparticles Female business Ovarian cancer |
| Zdroj: | SLAS technology. 24(2) |
| ISSN: | 2472-6311 |
| Popis: | Ovarian cancer is the fifth-most lethal cancer among women due to a lack of early detection and late-stage treatment options, and it is responsible for more than 14,000 deaths each year in the United States. Recently, there have been advances in RNA interference therapy, specifically with small interfering RNA (siRNA), to reduce tumor burden for ovarian cancer via gene down-regulation. However, delivery of siRNA poses its own challenges, as siRNA is unstable in circulation, is unable to be effectively internalized by cells, and may cause toxicity in off-target sites. To address such challenges, nanoparticle carriers have emerged as delivery platforms for the biocompatible, targeted delivery of siRNA-based therapies. Several preclinical studies have shown the promising effects of siRNA therapy to reduce chemotherapy resistance and proliferation of ovarian cancer cells. This review evaluates the recent advances, clinical applications, and future potential of nanoparticle-mediated delivery of siRNA therapeutics to target genes implicated in ovarian cancer. |
| Databáze: | OpenAIRE |
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