Dysexecutive syndrome: a specific pattern of cognitive impairment in systemic sclerosis
| Autor: | Nese Tuncer, Neslihan Yilmaz, Sule Yavuz, Hakan Gurvit, Meryem Can, Aynur Mollahasanoglu, Nevsun Inanc |
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| Rok vydání: | 2012 |
| Předmět: |
Nervous system
Adult Male Pathology medicine.medical_specialty Cognitive Neuroscience Neuropsychological Tests Scleroderma Executive Function Young Adult Memory medicine Humans In patient Attention Young adult skin and connective tissue diseases Cognitive impairment Aged Dysexecutive syndrome Scleroderma Systemic integumentary system Cerebral hypoperfusion business.industry Cognition General Medicine Middle Aged medicine.disease Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Female business Cognition Disorders |
| Zdroj: | Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 25(2) |
| ISSN: | 1543-3641 |
| Popis: | Systemic sclerosis (SSc) is a connective-tissue disorder characterized by microvascular damage and tissue fibrosis. Although overt nervous system involvement is unusual in SSc, imaging studies have shown cerebral hypoperfusion. We evaluated cognitive functions in patients with SSc who had no history of neurological involvement, to seek cognitive impairment caused by the suggested cerebral hypoperfusion.We performed a comprehensive neuropsychological test battery on 31 patients with SSc and on 2 groups of age-adjusted, sex-adjusted, and education-adjusted controls: 15 patients with rheumatoid arthritis and 20 healthy volunteers.The patients with SSc scored significantly worse on most of the measures of executive function than the 2 control groups (P0.05). However, both patient groups did worse than the healthy controls on measures of attention and memory (P0.005).Our results suggest that patients with SSc have a specific pattern of cognitive impairment: the dysexecutive syndrome. Attentional and memory problems, however, may arise from other confounders such as disease duration and chronic medication use. SSc may be a rare cause of vascular cognitive impairment. |
| Databáze: | OpenAIRE |
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