A prognostic model for predicting survival in cirrhosis with ascites
| Autor: | Llorenç Quintó, Wladimiro Jiménez, Pau Sort, Juan Uriz, Pere Ginès, Juan Rodés, Alberto Sanchez-Fueyo, Ramon Bataller, Andrés Cárdenas, Vicente Arroyo, Mónica Guevara, Pere Ventura, Gloria Fernández-Esparrach |
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| Rok vydání: | 2001 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis medicine.medical_treatment Hemodynamics Renal function Liver transplantation Models Biological Gastroenterology chemistry.chemical_compound Internal medicine Ascites medicine Humans Retrospective Studies Creatinine Hepatology business.industry Proportional hazards model Retrospective cohort study Middle Aged Prognosis medicine.disease Liver Transplantation Surgery chemistry Female medicine.symptom business |
| Zdroj: | Journal of Hepatology. 34:46-52 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(00)00011-8 |
| Popis: | Background/Aims : Parameters evaluating renal function and systemic hemodynamics are of prognostic significance in cirrhosis with ascites but are rarely used in the evaluation of survival of these patients. The aim of the current study was to develop a prognostic model to estimate survival of patients with cirrhosis and ascites. Methods : 216 Cirrhotic patients admitted to hospital for the treatment of ascites were evaluated. Thirty-two demographic, clinical and laboratory variables, including parameters assessing liver and renal function and systemic hemodynamics, were analyzed as predictive factors of survival by using a Cox regression model. Results : Four variables had independent prognostic value: renal water excretion, as assessed by measuring diuresis after water load, mean arterial pressure, Child–Pugh class, and serum creatinine. According to these features a prognostic index was calculated that allows to estimate survival in patients with cirrhosis and ascites. The model accurately predicted survival in an independent series of 84 patients with cirrhosis and ascites. Conclusion : A prognostic model that uses four easily available variables and predicts prognosis in cirrhotic patients with ascites has been developed. This model may be useful in the evaluation of patients with ascites for liver transplantation. |
| Databáze: | OpenAIRE |
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