No Renal Toxicity After Repeated Treatment with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Unresectable Peritoneal Metastasis
| Autor: | Mohammad Alyami, Olivier Glehen, Laurent Villeneuve, Frederic Mercier, Vahan Kepenekian, Nicolas Vantard, Isabelle Bonnefoy, Naoual Bakrin, Virginie Larbre, Marie-Agnès Opsomer, Catherine Rioufol |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Single Center Gastroenterology Drug Administration Schedule 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Recurrence Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Infusions Parenteral Doxorubicin Peritoneal Neoplasms Aged Retrospective Studies Aerosols Ovarian Neoplasms Cisplatin Chemotherapy business.industry Cancer General Medicine Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Toxicity Conventional PCI Peritoneal Cancer Index Female Kidney Diseases 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Anticancer Research. 38:6869-6875 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a recent approach for intraperitoneal chemotherapy with promising results for patients with peritoneal metastasis (PM). The aim of this study was to report renal toxicity for patients who received at least 3 repeated PIPAC procedures. Patients and methods All patients who underwent at least 3 PIPAC cycles of cisplatin (7.5 mg/m2) and doxorubicin (1.5 mg/m2) for unresectable PM from December 2015 to September 2017, were analysed regarding postoperative renal toxicity. Results Among 103 patients registered in a prospective single center database, 43 patients underwent at least 3 PIPAC cycles representing a total of 175 PIPAC. Median age was 59.8 years, 24 (55.8%) patients were female and median BMI was 22.2 kg/m2 Most common origins of PM were gastric 22 (51.1%) and ovarian 11 (25.6%) cancer. Median peritoneal cancer index (PCI) was 17 (range=5-39). For 39 (90.1%) patients, systemic chemotherapy was performed in addition to PIPAC. Forty-three (100%), 17 (39.5%), 14 (32.5%), 8 (18.6%), 3 (7%), 2 (4.7%) and 2 (4.7%) patients underwent three, four, five, six, seven, eight and nine PIPAC procedures, respectively. Repeated PIPAC did not induce significant acute nor cumulative renal toxicity in any patients. Conclusion Repeated PIPAC did not induce clinically relevant renal toxicity. This study confirms the previous published results in a larger group of patients. |
| Databáze: | OpenAIRE |
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