Cerebellar structure and function in the murine mutant 'jolting'
| Autor: | J.B. Harris, M.J. Cullen, R.J. Boakes, David J. Dick, J.M. Candy |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cerebellum Ataxia Neurofilament Ratón Purkinje cell Action Potentials Cell Count Biology Olivary Nucleus Cerebellar Cortex Mice Mice Neurologic Mutants Purkinje Cells medicine Extracellular Animals Cerebellar ataxia Age Factors medicine.anatomical_structure Neurology Cerebellar Nuclei Cerebellar cortex Female Neurology (clinical) medicine.symptom |
| Zdroj: | Journal of the neurological sciences. 76(2-3) |
| ISSN: | 0022-510X |
| Popis: | The morphology of the cerebellar cortex of the murine mutant “jolting” and its phenotypically normal littermate was studied. The general organisation of the cerebellum of normal mice was similar in all respects to that described for other vertebrate species. In “jolting” mice aged 4 months or more there was a marked loss of Purkinje cells and spheroids were present on Purkinje cell axons. An ultrastructural examination showed that the spheroids contained randomly orientated neurofilaments, degenerating mitochondria and autophagic vacuoles. The abnormalities in the cerebellum appeared confined to the Purkinje cells. Extracellular recordings were made of the electrical activity of the cerebellar cortex of anaesthetised mice. In the cerebellar cortex of “jolting” animals, Purkinje cells generated little spontaneous activity, but complex discharges resulting from climbing fibre inputs were indistinguishable from normal. The abnormal electrical activity of Purkinje cells in “jolting” mice could be seen in animals as young as 3 weeks. It was concluded that the “jolting” mouse suffers from a cerebellar ataxia. |
| Databáze: | OpenAIRE |
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