Acid-coated Textiles (pH 5.5–6.5) – a New Therapeutic Strategy for Atopic Eczema?
| Autor: | Teresa Jaeger, Mark D Anliker, Johannes Ring, Markus Rothmaier, Holger Zander, Jan Gutermuth |
|---|---|
| Přispěvatelé: | Surgical clinical sciences, Skin function and permeability |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythema Context (language use) Dermatology Electric Capacitance Citric Acid Dermatitis Atopic Young Adult chemistry.chemical_compound Double-Blind Method medicine Humans SCORAD Atopic Eczema Acid-coated Textiles Transepidermal Water Loss (tewl) Skin Capacitance Cellulose Barrier function Skin Medicine(all) Drug Carriers Transepidermal water loss medicine.diagnostic_test integumentary system business.industry Textiles General Medicine Hydrogen-Ion Concentration Middle Aged Water Loss Insensible Anti-Bacterial Agents ddc Tolerability Acid mantle chemistry TEWL Female Disease Susceptibility eczema medicine.symptom business Citric acid |
| Zdroj: | Acta Derm.-Venereol. 95, 659-663 (2015) |
| Popis: | Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined to date. A textile carrier composed of cellulose fibres was coated with a citric acid surface layer by esterification, ensuring a constant pH of 5.5-6.5. Twenty patients with AE or atopic diathesis were enrolled in the study. In a double-blind, half-side experiment, patients had to wear these textiles for 12 h a day for 14 days. On day 0 (baseline), 7 and 14, tolerability (erythema, pruritus, eczema, wearing comfort) and efficacy on skin barrier were assessed by TEWL skin hydration (corneometry/ capacitance), pH and clinical scoring of eczema (SCO-RAD). Citric acid-coated textiles were well tolerated and improved eczema and objective parameters of skin physiology, including barrier function and a reduced skin surface pH, with potential lower pathogenic microbial colonisation. |
| Databáze: | OpenAIRE |
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