Defective Interfering Viral Particle Treatment Reduces Clinical Signs and Protects Hamsters from Lethal Nipah Virus Disease

Autor:	Stephen R. Welch, Jessica R. Spengler, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Sarah C. Genzer, Michael K. Lo, Joel M. Montgomery, Stuart T. Nichol, Christina F. Spiropoulou
Rok vydání:	2022
Předmět:	Henipavirus Infections Disease Models Animal Mesocricetus Cricetinae viruses Virology Nipah Virus Virion Animals food and beverages Microbiology
Zdroj:	mBio. 13
ISSN:	2150-7511
DOI:	10.1128/mbio.03294-21
Popis:	Here, we demonstrate that treatment with defective interfering particles (DIs), a natural by-product of viral infection, can significantly improve the clinical course and outcome of viral disease. When present with their parental virus, DIs can directly or indirectly alter viral propagation kinetics and exert potent inhibitory properties in cell culture.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c414266a7ef2356162384f6ba56966a https://doi.org/10.1128/mbio.03294-21 Zobrazit plný text záznamu