Human Herpesvirus 6 Encephalitis in Immunocompetent and Immunocompromised Hosts
| Autor: | Giulia Campanini, Oscar Borsani, Francesca Compagno, Thomas Foiadelli, Fausto Baldanti, Giulia Berzero, Anna Amelia Colombo, Angela Di Matteo, Paolo Bernasconi, Enrico Marchioni, Virginia Rossi, Matteo Paoletti, Salvatore Savasta, Anna Pichiecchio, Anna Simoncelli, Marco Zecca, Elisa Vegezzi |
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| Přispěvatelé: | Berzero, G., Campanini, G., Vegezzi, E., Paoletti, M., Pichiecchio, A., Simoncelli, A. M., Colombo, A. A., Bernasconi, P., Borsani, O., Di Matteo, A., Rossi, V., Foiadelli, T., Savasta, S., Compagno, F., Zecca, M., Baldanti, F., Marchioni, E. |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent viruses Herpesvirus 6 Human Encephalopathy Roseolovirus Infections Clinical settings Antiviral Agents Article Immunocompromised Host Young Adult Seizures medicine Human herpesvirus 6 encephalitis Humans Encephalitis Viral Retrospective Studies biology business.industry Hematopoietic Stem Cell Transplantation virus diseases medicine.disease biology.organism_classification Neurology Immunology Female Human herpesvirus 6 Neurology (clinical) business Encephalitis |
| Zdroj: | Neurology® Neuroimmunology & Neuroinflammation article-version (Version of Record) 3 |
| ISSN: | 2332-7812 |
| DOI: | 10.1212/nxi.0000000000000942 |
| Popis: | ObjectiveThe aim of this study was to analyze the clinical, radiologic, and biological features associated with human herpesvirus 6 (HHV-6) encephalitis in immunocompetent and immunocompromised hosts to establish which clinical settings should prompt HHV-6 testing.MethodsWe performed a retrospective research in the virology database of Fondazione IRCCS Policlinico San Matteo (Pavia, Italy) for all patients who tested positive for HHV-6 DNA in the CSF and/or in blood from January 2008 to September 2018 and separately assessed the number of patients meeting the criteria for HHV-6 encephalitis in the group of immunocompetent and immunocompromised hosts.ResultsOf the 926 patients tested for HHV-6 during the period of interest, 45 met the study criteria. Among immunocompetent hosts (n = 17), HHV-6 encephalitis was diagnosed to 4 infants or children presenting with seizures or mild encephalopathy during primary HHV-6 infection (CSF/blood replication ratio <1.ConclusionsThe detection of a CSF/blood replication ratio >1 represented a specific feature of immunocompromised patients with HHV-6 encephalitis and could be of special help to establish a diagnosis of HHV-6 encephalitis in hematopoietic stem cell transplant recipients lacking radiologic evidence of limbic involvement. |
| Databáze: | OpenAIRE |
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