Testicular Function and Glycemic Control in Diabetic Men A Controlled Study*
| Autor: | David J. Handelsman, Lyn M. Boylan, Dennis K. Yue, John R. Turtle, Ann J. Conway |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose Male endocrine system medicine.medical_specialty Urology Semen Testicle Endocrinology Internal medicine Diabetes mellitus Testis medicine Humans Testosterone Sperm motility Glycemic Glycated Hemoglobin Sperm Count urogenital system business.industry General Medicine Luteinizing Hormone Middle Aged medicine.disease Neurovascular bundle Prolactin Diabetes Mellitus Type 1 medicine.anatomical_structure Sperm Motility Hemoglobin Follicle Stimulating Hormone business Spermatogenesis |
| Zdroj: | Andrologia. 17:488-496 |
| ISSN: | 1439-0272 0303-4569 |
| DOI: | 10.1111/j.1439-0272.1985.tb01047.x |
| Popis: | We have investigated testicular function in 28 insulin-dependent diabetic men under the age of 50 years and 119 age-matched controls. Diabetics had reduced testicular volume, semen volume, total and total motile sperm output while plasma LH and FSH levels were elevated. Reduction in semen volume and impotence were more common in long-standing complicated diabetes. Glycosylated hemoglobin (GHb) levels were positively correlated with plasma LH levels (r = 0.46, p less than 0.02) but there was no direct correlation of glycemic control and spermatogenesis. The differences in testicular function were due to decreased spermatogenesis and could not be explained by other forms of testicular pathology or the presence of diabetic neurovascular complications. We conclude that the function of the hypothalamic pituitary testicular axis is impaired in diabetic men, that this impairment is at least partly related to the degree of preceding glycemic control and that multiple levels of the axis may be dysfunctional. |
| Databáze: | OpenAIRE |
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