Effects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models: a systematic review and meta-analysis
| Autor: | Zhenggang Ren, Jing-Huan Li, Yan-Hong Wang, Wen-Shuai Fan, Mi-Mi Wang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Neoplasm metastasis lcsh:Medicine Review Mesenchymal Stem Cell Transplantation General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Animals Humans Animal model Solid tumor Tumor microenvironment business.industry Incidence (epidemiology) lcsh:R Mesenchymal stem cell Cancer General Medicine Publication bias medicine.disease Disease Models Animal Meta-analysis 030104 developmental biology 030220 oncology & carcinogenesis Mesenchymal stem cells business Publication Bias |
| Zdroj: | Journal of Translational Medicine Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018) |
| ISSN: | 1479-5876 |
| Popis: | Background It has been reported mesenchymal stem cells (MSCs) are recruited to and become integral parts of the tumor microenvironment. MSCs might have an active role in solid tumor progression, especially cancer metastasis. However, the contribution of MSCs in the process of cancer metastasis is still controversial. In this review, we performed a meta-analysis on the effects of MSCs administration on cancer metastasis based on published preclinical studies. Methods The PRISMA guidelines were used. A total of 42 publications met the inclusion criteria. Outcome data on the incidence and the number of cancer metastasis as well as study characteristics were extracted. Quality of the studies was assessed according to SYRCLE Risk of Bias tool. Random-effects meta-analysis was used to pool estimates. Results Of the 42 studies included, 32 reported that MSCs administration promoted outcome events (numbers or incidences of cancer metastasis), and 39 reported data suitable for meta-analysis. The median effect size (RR) was 2.04 for the incidence of cancer metastasis (95% CI 1.57–2.65, I2 = 21%), and the median effect size (SMD) was 1.23 for the number of cancer metastasis (95% CI 0.43–2.03, I2 = 89%). Heterogeneity was observed, with the greater impact based on study length and different ways of metastasis measurement and MSCs administration. Conclusion Our results suggested MSCs administration increased the number and the incidence of cancer metastasis in experimental cancer models. High heterogeneity and poor reported risk of bias limit the quality of these findings. Further preclinical studies with better design and adequate reporting are still needed. Electronic supplementary material The online version of this article (10.1186/s12967-018-1484-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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