RETINAL HYPERREFLECTIVE FOCI IN TYPE 1 DIABETES MELLITUS

Autor: Vivian Schreur, Anita de Breuk, Eiko K. de Jong, Clara I. Sánchez, Cees J. Tack, Freerk G. Venhuizen, Carel B. Hoyng, B. Jeroen Klevering
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
endocrine system diseases
genetic structures
Diabetic macular edema
Visual Acuity
Slit Lamp Microscopy
Macular Edema
Retina
Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
All institutes and research themes of the Radboud University Medical Center
Optical coherence tomography
image analysis
Ophthalmology
Photography
Medicine
Humans
In patient
Original Study
030212 general & internal medicine
Aged
Type 1 diabetes
Diabetic Retinopathy
optical coherence tomography
medicine.diagnostic_test
business.industry
hyperreflective foci
Retinal
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
eye diseases
Hyperreflective foci
Diabetes Mellitus
Type 1
chemistry
030221 ophthalmology & optometry
Female
business
diabetic macular edema
Tomography
Optical Coherence
Zdroj: Retina-The Journal of Retinal and Vitreous Diseases, 40, 8, pp. 1565-1573
Retina-The Journal of Retinal and Vitreous Diseases, 40, 1565-1573
Retina (Philadelphia, Pa.)
ISSN: 0275-004X
Popis: Hyperreflective foci on OCT may be a potential biomarker for treatment response and disease progression in diabetic retinal disease. In this study of Type 1 diabetics, associations were found between hyperreflective foci and disease severity and with both morphological and clinical characteristics.
Purpose: To investigate hyperreflective foci (HF) on spectral-domain optical coherence tomography in patients with Type 1 diabetes mellitus across different stages of diabetic retinopathy (DR) and diabetic macular edema (DME) and to study clinical and morphological characteristics associated with HF. Methods: Spectral-domain optical coherence tomography scans and color fundus photographs were obtained of 260 patients. Spectral-domain optical coherence tomography scans were graded for the number of HF and other morphological characteristics. The distribution of HF across different stages of DR and DME severity were studied. Linear mixed-model analysis was used to study associations between the number of HF and clinical and morphological parameters. Results: Higher numbers of HF were found in patients with either stage of DME versus patients without DME (P < 0.001). A trend was observed between increasing numbers of HF and DR severity, although significance was only reached for moderate nonproliferative DR (P = 0.001) and proliferative DR (P = 0.019). Higher numbers of HF were associated with longer diabetes duration (P = 0.029), lower high-density lipoprotein cholesterol (P = 0.005), and the presence of microalbuminuria (P = 0.005). In addition, HF were associated with morphological characteristics on spectral-domain optical coherence tomography, including central retinal thickness (P = 0.004), cysts (P < 0.001), subretinal fluid (P = 0.001), and disruption of the external limiting membrane (P = 0.018). Conclusion: The number of HF was associated with different stages of DR and DME severity. The associations between HF and clinical and morphological characteristics can be of use in further studies evaluating the role of HF as a biomarker for disease progression and treatment response.
Databáze: OpenAIRE
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