Development of amphotericin B-loaded cubosomes through the SolEmuls technology for enhancing the oral bioavailability
| Autor: | Linghui Dian, Meiwan Chen, Chuanbin Wu, Zhiwen Yang, Xinsheng Peng, Ziyun Shan, Yinhe Tan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
animal diseases Chemistry Pharmaceutical Pharmaceutical Science Administration Oral Biological Availability Aquatic Science Pharmacology Acute nephrotoxicity Nephrotoxicity Rats Sprague-Dawley Drug Stability X-Ray Diffraction Oral administration Amphotericin B Drug Discovery parasitic diseases medicine Animals Technology Pharmaceutical Tissue Distribution Tissue distribution Particle Size Ecology Evolution Behavior and Systematics Ecology Chemistry Liquid crystalline urogenital system technology industry and agriculture General Medicine bacterial infections and mycoses Bioavailability Anti-Bacterial Agents Liquid Crystals Rats Sprague dawley Nanoparticles Agronomy and Crop Science medicine.drug Research Article |
| Zdroj: | AAPS PharmSciTech. 13(4) |
| ISSN: | 1530-9932 |
| Popis: | The oral administration of amphotericin B (AmB) has the major drawback of poor bioavailability. The aim of this work was to evaluate the potential of AmB-loaded cubosomes as an oral formulation with improved bioavailability. This manuscript firstly developed AmB-loaded cubosomes by using the SolEmuls technology. The encapsulation efficiency, the in vitro release, and stability studies in simulated gastrointestinal fluid were used to evaluate AmB-loaded cubosomes. The acute nephrotoxicity, bioavailability, and tissue distribution study of AmB-loaded cubosomes were assayed upon oral administration to rats. SAXS and cryo-TEM exhibited AmB-loaded cubosomes as a bicontinuous cubic liquid crystalline phase with Pn3m geometry. The encapsulation efficiency and the results of in vitro release and stability studies in simulated gastrointestinal fluid further demonstrated that AmB was successfully encapsulated in cubosomes. AmB-loaded cubosomal formulation orally administrated in rats did not show nephrotoxicity and its relative bioavailability was approximately 285% as compared to Fungizone®. The AmB-loaded cubosomal formulation presented an effective potential approach for enhancing the oral bioavailability of AmB. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink