Study of serum factors potentially involved in the pathogenesis of heterotopic bone formation after severe brain injury
| Autor: | Pascal Rigaux, Bruno Sutter, Karine Anselme, Danielle Darriet, Christophe Delecourt, Anne-France Dudermel, Pierre Hardouin, Vincent Chieux, Nassima Benabid |
|---|---|
| Přispěvatelé: | Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Population 030209 endocrinology & metabolism Choristoma leptin Bone and Bones Bone remodeling Pathogenesis osteoma Fractures Bone 03 medical and health sciences 0302 clinical medicine Rheumatology medicine Humans Prospective Studies Prospective cohort study education Osteoma 030304 developmental biology 2. Zero hunger heterotopic bone formation 0303 health sciences education.field_of_study Trauma Severity Indices business.industry Leptin Head injury medicine.disease 3. Good health Brain Injuries Alkaline phosphatase [SDV.IB]Life Sciences [q-bio]/Bioengineering business alkaline phosphatase head injury |
| Zdroj: | Joint Bone Spine Joint Bone Spine, Elsevier Masson, 2005, 72 (2), pp.146-149. ⟨10.1016/j.jbspin.2004.05.012⟩ |
| ISSN: | 1297-319X |
| DOI: | 10.1016/j.jbspin.2004.05.012⟩ |
| Popis: | Objective. – To look for serum factors detectable early after head injury and predictive of heterotopic bone formation. Patients and methods. – In this prospective study of a homogeneous population of 31 men with severe brain injury, blood samples were obtained 3 months after the accident, and levels of serum factors influenced by bone metabolism were compared between patients with and without heterotopic bone formation. As extensive fractures can influence serum factors, the patients without heterotopic bone formation were divided into two groups based on whether they had major fractures. Radionuclide bone scanning was used to validate patient classification. Results. – The group with heterotopic bone formation had significantly higher serum alkaline phosphatase levels (P < 0.01) and significantly lower serum leptin levels (P < 0.01), as compared to the other two groups. Body mass index and serum creatinine were comparable in the three groups. Conclusion. – Leptin may be associated with the development of heterotopic bone formation. The antiosteogenic effect of leptin mediated by hypothalamic neurons may be impaired by hypothalamic damage related to severe brain injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect