Urinary Excretion of N1-Methylnicotinamide and N1-Methyl-2-Pyridone-5-Carboxamide and Mortality in Kidney Transplant Recipients
| Autor: | Johanna M. Geleijnse, Carolien P J Deen, Ido P. Kema, Stephan J. L. Bakker, M. Rebecca Heiner-Fokkema, António W Gomes-Neto, Anna van der Veen, Karin J Borgonjen-van den Berg |
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| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Lifestyle Medicine (LM), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Nutrition and Disease lcsh:TX341-641 urinary excretion OS&DAEB Kidney transplant Gastroenterology vitamin B3 N1-methylnicotinamide Excretion 03 medical and health sciences Urinary excretion Internal medicine Voeding en Ziekte medicine tryptophan VLAG N1-methyl-2-pyridone-5-carboxamide 030109 nutrition & dietetics Nutrition and Dietetics Proportional hazards model business.industry Confounding renal transplantation mortality Transplantation 030104 developmental biology niacin status business dietary intake lcsh:Nutrition. Foods and food supply N1 methylnicotinamide Niacin Food Science |
| Zdroj: | Nutrients, 12(7):2059, 1-18. MDPI AG Nutrients Volume 12 Issue 7 Nutrients, 12(7) Nutrients 12 (2020) 7 Nutrients, Vol 12, Iss 2059, p 2059 (2020) |
| ISSN: | 2072-6643 |
| Popis: | It is unclear whether niacin nutritional status is a target for improvement of long-term outcome after renal transplantation. The 24-h urinary excretion of N1-methylnicotinamide (N1-MN), as a biomarker of niacin status, has previously been shown to be negatively associated with premature mortality in kidney transplant recipients (KTR). However, recent evidence implies higher enzymatic conversion of N1-MN to N1-methyl-2-pyridone-5-carboxamide (2Py) in KTR, therefore the need exists for interpretation of both N1-MN and 2Py excretion for niacin status assessment. We assessed niacin status by means of the 24-h urinary excretion of the sum of N1-MN and 2Py (N1-MN + 2Py), and its associations with risk of premature mortality in KTR. N1-MN + 2Py excretion was measured in a longitudinal cohort of 660 KTR with LS-MS/MS. Prospective associations of N1-MN + 2Py excretion were investigated with Cox regression analyses. Median N1-MN + 2Py excretion was 198.3 (155.9&ndash 269.4) µ mol/day. During follow-up of 5.4 (4.7&ndash 6.1) years, 143 KTR died, of whom 40 due to an infectious disease. N1-MN + 2Py excretion was negatively associated with risk of all-cause mortality (HR 0.61 95% CI 0.47&ndash 0.79 p < 0.001), and infectious mortality specifically (HR 0.47 95% CI 0.29&ndash 0.75 p = 0.002), independent of potential confounders. Secondary analyses showed effect modification of hs-CRP on the negative prospective association of N1-MN + 2Py excretion, and sensitivity analyses showed negative and independent associations of N1-MN and 2Py excretion with risk of all-cause mortality separately. These findings add further evidence to niacin status as a target for nutritional strategies for improvement of long-term outcome in KTR. |
| Databáze: | OpenAIRE |
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