Association between changes in fat distribution and biomarkers for breast cancer
| Autor: | Anne M. May, Evelyn M. Monninkhof, Maaike Stapper, Wouter B. Veldhuis, Sjoerd G. Elias, Petra H.M. Peeters, Rebecca K. Stellato, Willemijn A.M. van Gemert, Jantine A. Schuit, Job van der Palen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Leptin
Cancer Research Endocrinology Diabetes and Metabolism postmenopausal women Overweight LONG EXERCISE INTERVENTION breast cancer risk 0302 clinical medicine Endocrinology Sex hormone-binding globulin Risk Factors Weight loss Sex Hormone-Binding Globulin Body Fat Distribution Testosterone METABOLIC RISK skin and connective tissue diseases Abdominal obesity education.field_of_study Estradiol biology 11 Medical And Health Sciences Middle Aged Postmenopause RANDOMIZED CLINICAL-TRIAL body fat C-Reactive Protein Adipose Tissue Oncology ABDOMINAL OBESITY 030220 oncology & carcinogenesis Female CIRCULATING ADIPONECTIN Adiponectin SUBCUTANEOUS ADIPOSE-TISSUE medicine.symptom Life Sciences & Biomedicine hormones hormone substitutes and hormone antagonists medicine.medical_specialty Population BODY-FAT WEIGHT-LOSS Breast Neoplasms 030209 endocrinology & metabolism Endocrinology & Metabolism 03 medical and health sciences Classification of obesity Internal medicine Weight Loss medicine Journal Article Humans Oncology & Carcinogenesis TANDEM MASS-SPECTROMETRY education Exercise Aged Science & Technology Interleukin-6 business.industry abdominal fat biomarkers 06 Biological Sciences n/a OA procedure Diet biology.protein business |
| Zdroj: | Endocrine-Related Cancer, 24(6), 297-305. Society for Endocrinology Endocrine-related cancer, 24(6), 297-305. Society for Endocrinology Endocrine-Related Cancer, 24(6), 297. Society for Endocrinology |
| ISSN: | 1351-0088 |
| DOI: | 10.1530/erc-16-0490 |
| Popis: | We assessed the associations between changes in total and abdominal fat and changes in biomarkers for breast cancer risk using data of the SHAPE-2 trial. In the SHAPE-2 trial, 243 postmenopausal overweight women were included. The intervention in this trial consisted of 5-6 kg weight loss either by diet only or exercise plus diet. After 16 weeks, we measured serum sex hormones, inflammatory markers, total body fat (measured by DEXA scan) and intra and subcutaneous abdominal fat (measured by MRI). Associations between changes in different body fat depots and biomarkers were analysed by linear regression using the study cohort irrespective of randomisation to make maximal use of the distribution of changes in fat measures. We found that a loss in total body fat was associated with favourable changes in free oestradiol, free testosterone, leptin and sex hormone binding globulin (SHBG). The loss of intra-abdominal fat was associated with a decrease in free testosterone, hsCRP and leptin, and an increase in SHBG. In the multivariable analysis, the best fitted models for the biomarkers free oestradiol, SHBG leptin and adiponectin included only total body fat. For free testosterone, this was subcutaneous abdominal fat, and for hsCRP and IL-6, only intra-abdominal fat change was important. For IL-6 and adiponectin, however, associations were weak and not significant. We conclude that, in our population of healthy overweight postmenopausal women, loss of fat at different body locations was associated with changes in different types of biomarkers, known to be related to risk of breast cancer. |
| Databáze: | OpenAIRE |
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