Randomized trial of polychromatic blue-enriched light for circadian phase shifting, melatonin suppression, and alerting responses
| Autor: | Steven W. Lockley, John P. Hanifin, Benjamin Warfield, Carissa Pineda, Edward Gerner, Michael R. Jablonski, Kate S. Cecil, Brenda Byrne, Mary E. James, Kathleen E. West, Melissa A. Ayers, George C. Brainard, Mark D. Rollag |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Sleepiness Circadian phase Light Experimental and Cognitive Psychology Photon density law.invention Melatonin Young Adult 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Fluorescent light Randomized controlled trial law Internal medicine Reaction Time medicine Humans Attention 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Circadian rhythm Wakefulness business.industry 05 social sciences Circadian Rhythm Alertness Endocrinology Clock time Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Physiology & Behavior. 198:57-66 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2018.10.004 |
| Popis: | Wavelength comparisons have indicated that circadian phase-shifting and enhancement of subjective and EEG-correlates of alertness have a higher sensitivity to short wavelength visible light. The aim of the current study was to test whether polychromatic light enriched in the blue portion of the spectrum (17,000 K) has increased efficacy for melatonin suppression, circadian phase-shifting, and alertness as compared to an equal photon density exposure to a standard white polychromatic light (4000 K). Twenty healthy participants were studied in a time-free environment for 7 days. The protocol included two baseline days followed by a 26-h constant routine (CR1) to assess initial circadian phase. Following CR1, participants were exposed to a full-field fluorescent light (1 × 1014 photons/cm2/s, 4000 K or 17,000 K, n = 10/condition) for 6.5 h during the biological night. Following an 8 h recovery sleep, a second 30-h CR was performed. Melatonin suppression was assessed from the difference during the light exposure and the corresponding clock time 24 h earlier during CR1. Phase-shifts were calculated from the clock time difference in dim light melatonin onset time (DLMO) between CR1 and CR2. Blue-enriched light caused significantly greater suppression of melatonin than standard light ((mean ± SD) 70.9 ± 19.6% and 42.8 ± 29.1%, respectively, p |
| Databáze: | OpenAIRE |
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