Acute necrotizing pancreatitis as a fatal complication�following DC Bead transcatheter arterial chemoembolization for hepatocellular carcinoma: A case report and review of the literature
| Autor: | Miki Murata, Rinako Tsuda, Toshihito Seki, Takashi Yamaguchi, Yoko Harima, Kanehiko Suwa, Ryosuke Inokuchi, Kazuichi Okazaki, Atsushi Komemushi, Michiko Yuki |
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| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
medicine.medical_specialty business.industry Articles medicine.disease 030218 nuclear medicine & medical imaging Surgery Gastroduodenal artery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology Embolism Celiac artery medicine.artery medicine Acute pancreatitis 030211 gastroenterology & hepatology Superior mesenteric artery Esophagus Transcatheter arterial chemoembolization Pancreas business |
| Zdroj: | Molecular and Clinical Oncology. |
| ISSN: | 2049-9469 2049-9450 |
| DOI: | 10.3892/mco.2018.1690 |
| Popis: | Transcatheter arterial chemoembolization (TACE) is one of the most effective palliative measures for patients with inoperable hepatocellular carcinoma (HCC). Acute pancreatitis is a rare but well-known complication following TACE. We herein present the case of a patient with HCC who developed fatal complications (acute necrotizing pancreatitis and upper gastrointestinal ulcers) after TACE with DC Beads. The patient was diagnosed with HCC in segments 4 and 8, measuring ~70 mm in greatest diameter, and he was treated by TACE. Hepatic arteriography revealed replacement of the origin of the right hepatic artery to the superior mesenteric artery, while the left hepatic artery originated from the celiac artery. After selection of the segmental arterial branches feeding the tumor, 2 ml of 100–300-µm-sized DC Beads loaded with 150 mg epirubicin were injected through the microcatheter. The patient complained of abdominal pain after the TACE procedure. Upper gastrointestinal endoscopy revealed longitudinal ulcers from the esophagus to the duodenum, and contrast-enhanced computed tomography revealed swelling of the pancreas and focal areas of low density in the pancreatic body, suggesting necrosis. The patient developed respiratory insufficiency, renal failure and sepsis, and finally succumbed to the complications 54 days after the procedure, despite general management of the acute pancreatitis. An autopsy revealed that the main cause of the patient's death was extensive pancreatic necrosis due to a gastroduodenal artery embolism after TACE with DC Beads. Therefore, it is crucial for treating physicians to be aware of this complication following TACE with DC Beads, particularly in patients with anatomical variations. |
| Databáze: | OpenAIRE |
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