Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions
| Autor: | Puiggros, Anna, Collado, Rosa, Calasanz, M.J, Ortega, Margarita, Ruiz-Xivillé, Neus, Rivas-Delgado, Alfredo, Luño, Elisa, González, Teresa, Navarro, Blanca, García-Malo, MaDolores, Valiente, Alberto, Hernández, José Ángel, Ardanaz, María Teresa, Piñan, María Ángeles, Blanco, María Laura, Hernández-Sánchez, María, Batlle-López, Ana, Salgado Sánchez, Rocío Nieves, Salido, Marta, Ferrer, Ana, Abrisqueta, Pau, Gimeno, Eva, Abella Monreal, Eugenia, Ferrá, Christelle, Terol, María José, Ortuño, Francisco, Costa, Dolors, Moreno, Carol, Carbonell, Félix, Bosch José, Francesc Xavier, Delgado, Julio, Espinet i Solà, Blanca, Universitat Autònoma de Barcelona |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Generalitat de Catalunya |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gynecology medicine.medical_specialty complex karyotype Adverse outcomes business.industry Complex karyotype ATM deletion TP53 deletion 03 medical and health sciences Leucèmia limfoblàstica -- Aspectes genètics 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Advanced disease Overall survival Medicine Fish business Cariotips CLL Research Paper |
| Zdroj: | Oncotarget r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Digital.CSIC. Repositorio Institucional del CSIC |
| ISSN: | 1949-2553 |
| Popis: | Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH) in a cohort of 1045 untreated MBL/CLL patients. In all, 99/1045 (9.5%) patients displayed a CK. Despite ATM and TP53 deletions were more common in CK (25% vs 7%; P < 0.001; 40% vs 5%; P < 0.001, respectively), only 44% (40/90) patients with TP53 deletions showed a CK. CK group showed a significant higher two-year cumulative incidence of treatment (48% vs 20%; P < 0.001), as well as a shorter overall survival (OS) (79 mo vs not reached; P < 0.001). When patients were categorized regarding CK and HR-FISH, those with both characteristics showed the worst median OS (52 mo) being clearly distinct from those non-CK and non-HR-FISH (median not reached), but no significant differences were detected between cases with only CK or HR-FISH. Both CK and TP53 deletion remained statistically significant in the multivariate analysis for OS. In conclusion, CK group is globally associated with advanced disease and poor prognostic markers. Further investigation in larger cohorts with CK lacking HR-FISH is needed to elucidate which mechanisms underlie the poor outcome of this subgroup. This work has been supported by the following grants: PI11/01621, PI15/00437, RD12/0036/0044, RD12/0036/0069 and PT13/0010/0005 FEDER, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness; 2014/SGR585 from Generalitat de Catalunya. |
| Databáze: | OpenAIRE |
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