The Number Needed to Vaccinate (NNV) against herpes zoster: a systematic review with meta-analysis

Autor:	George N. Okoli, Yahya Al-Yousif, Viraj K. Reddy, Mê-Linh Lê, Christine J. Neilson, Ahmed M. Abou-Setta
Rok vydání:	2021
Předmět:	Microbiology (medical) Herpesvirus 3 Human Infectious Diseases General Immunology and Microbiology Vaccination Vaccines Subunit Herpes Zoster Vaccine Humans General Medicine Vaccines Attenuated Herpes Zoster
Zdroj:	Infectious Diseases. 54:356-366
ISSN:	2374-4243 2374-4235
Popis:	The number needed to vaccinate (NNV) quantifies the effectiveness of vaccination programs. We summarised the published data on NNV against herpes zoster to inform vaccination policies.We systematically identified studies based on a priori established and registered methods. The main outcomes were the NNV against herpes zoster infection, hospitalisation and mortality. Where appropriate, we conducted meta-analyses using inverse variance, random-effects models, pooling estimated NNV with associated 95% confidence interval (CI). Statistical heterogeneity between pooled estimates was calculated using theOut of 229 unique citations, we included eight nonrandomized studies. Among 50+ year-olds, the NNV against herpes zoster infection using the recombinant subunit vaccine was 11 (95%CI 8-14;Evidence on the NNV against herpes zoster is scarce. Vaccination with the recombinant subunit herpes zoster vaccine may be more effective than with the live attenuated vaccine in preventing infection among 50+ year-olds. More studies are needed for a stronger evidence base for decision-making.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c32d248b3dd15565e7b5d49a78bac65 https://doi.org/10.1080/23744235.2021.2018493 Zobrazit plný text záznamu