Differences in hippocampal serotonergic activity in a mouse single prolonged stress paradigm impact discriminant fear acquisition and retention
| Autor: | Deane Aikins, Shane A. Perrine, Nina Bihani, Robert J. Kohler, John A. Strader |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Conditioning Classical Hippocampus Hippocampal formation Serotonergic Fear-potentiated startle Developmental psychology Extinction Psychological Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Animals Fear conditioning Fear processing in the brain General Neuroscience Traumatic stress Retention Psychology Fear Mice Inbred C57BL Disease Models Animal 030104 developmental biology Serotonin Cues Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience letters. 639 |
| ISSN: | 1872-7972 |
| Popis: | A mouse model of traumatic stress provided insight into a mechanism of individual differences in conditioned fear responding. Hippocampal serotonergic activity (metabolic turnover) was associated with increased behavioral freezing during fear acquisition in a portion of trauma-exposed subjects. These subjects later displayed enhanced fear to the neutral cue during retention. An inability to discriminate fear responses may underlie dysfunctional fear memories in a sub-population of individuals with Posttraumatic Stress Disorder, with contributions from the hippocampal serotonin system. |
| Databáze: | OpenAIRE |
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