Neuroglial-specific factors and the regulation of retrovirus transcription
| Autor: | Renee Wessner, Maribeth Tillmann, Brian Wigdahl, Fred C. Krebs, Maureen M. Goodenow, Steven M. Pomeroy |
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| Rok vydání: | 1994 |
| Předmět: |
Gene Expression Regulation
Viral Transcriptional Activation AIDS Dementia Complex Transcription Genetic viruses Recombinant Fusion Proteins Immunology Molecular Sequence Data Genome Viral Malignancy Genome Models Biological Virus Pathogenesis Immune system Retrovirus Transcription (biology) medicine Humans Cells Cultured HIV Long Terminal Repeat Repetitive Sequences Nucleic Acid Human T-lymphotropic virus 1 biology Base Sequence General Neuroscience Gene Products tax medicine.disease biology.organism_classification Virology Long terminal repeat HIV-1 Microglia Neuroglia Transcription Factors |
| Zdroj: | Advances in neuroimmunology. 4(3) |
| ISSN: | 0960-5428 |
| Popis: | Retroviruses have been implicated as causative agents of a variety of human diseases including malignancy, immune system dysfunction, and neurologic disorders. Despite the isolation of various retroviral agents from patients suffering from malignant neoplasias and neurologic disorders, only the human T-cell lymphotropic virus type I (HTLV-I) and the human immunodeficiency virus (HIV) have been definitively accepted as etiologic agents of human disease (Hjelle, 1991; Gessain and Gout, 1992; Rosenblatt, 1993). Because of their increasingly defined roles in disease progression, the replication of HTLV-I and HIV is an important focus for understanding the pathogenic processes resulting from viral infection. Of particular interest are the molecular mechanisms by which expression of retroviral genomes is regulated by their regulatory units, the long terminal repeats (LTR), in a manner specific to the cellular targets which they infect. |
| Databáze: | OpenAIRE |
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