The prognostic value of the number of positive lymph nodes and the lymph node ratio in early‐stage cervical cancer

Autor: Ester P. Olthof, Constantijne H. Mom, Malou L. H. Snijders, Hans H. B. Wenzel, Jacobus van der Velden, Maaike A. van der Aa
Přispěvatelé: Graduate School, Pathology, CCA -Cancer Center Amsterdam, Obstetrics and Gynaecology, CCA - Imaging and biomarkers, Amsterdam Reproduction & Development (AR&D), Obstetrics and gynaecology
Rok vydání: 2022
Předmět:
Zdroj: Acta obstetricia et gynecologica Scandinavica, 101(5), 550-557. Wiley-Blackwell
Acta Obstetricia et Gynecologica Scandinavica, 101(5), 550-557. Wiley-Blackwell
Olthof, E P, Mom, C H, Snijders, M L H, Wenzel, H H B, van der Velden, J & van der Aa, M A 2022, ' The prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer ', Acta Obstetricia et Gynecologica Scandinavica, vol. 101, no. 5, pp. 550-557 . https://doi.org/10.1111/aogs.14316
ISSN: 1600-0412
0001-6349
DOI: 10.1111/aogs.14316
Popis: Introduction: To establish the impact of the number of lymph node metastases (nLNM) and the lymph node ratio (LNR) on survival in patients with early-stage cervical cancer after surgery. Material and methods: In this nationwide historical cohort study, all women diagnosed between 1995 and 2020 with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA2–IIA1 cervical cancer and nodal metastases after radical hysterectomy and pelvic lymphadenectomy from the Netherlands Cancer Registry were selected. Optimal cut-offs for prognostic stratification by nLNM and LNR were calculated to categorize patients into low-risk or high-risk groups. Kaplan–Meier overall survival analysis and flexible parametric relative survival analysis were used to determine the impact of nLNM and LNR on survival. Missing data were imputed. Results: The optimal cut-off point was ≥4 for nLNM and ≥0.177 for LNR. Of the 593 women included, 500 and 501 (both 84%) were categorized into the low-risk and 93 and 92 (both 16%) into the high-risk groups for nLNM and LNR, respectively. Both high-risk groups had a worse 5-year overall survival (p
Databáze: OpenAIRE
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