Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules
| Autor: | Carlos C. Romão, Luís Raposo, Alexandra R. Fernandes, Joana Marques, Inês Mendonça-Martins, Rita Mendes, Pedro V. Baptista, Maria João Romão, Teresa Santos-Silva, Marino F. A. Santos |
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| Rok vydání: | 2020 |
| Předmět: |
Carbon Monoxide
biology Chemistry 0206 medical engineering Biomedical Engineering Metal Nanoparticles Nanoparticle Metal carbonyl 02 engineering and technology 021001 nanoscience & nanotechnology 020601 biomedical engineering Biomaterials Anti-inflammatory response Coordination Complexes Colloidal gold Vectorization (mathematics) Organometallic Compounds biology.protein Biophysics Molecule Gold Bovine serum albumin 0210 nano-technology |
| Zdroj: | ACS Biomaterials Science & Engineering. 6:1090-1101 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.9b01936 |
| Popis: | CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles-CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO) |
| Databáze: | OpenAIRE |
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