Gamma oscillations in the somatosensory thalamus of a patient with a phantom limb: case report
| Autor: | Mojgan Hodaie, Diellor Basha, William D. Hutchison, Andres M. Lozano, Jonathan O. Dostrovsky, Suneil K. Kalia |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Deep brain stimulation medicine.medical_treatment Essential Tremor Thalamus Phantom limb Thalamocortical dysrhythmia Local field potential Somatosensory system Imaging phantom 03 medical and health sciences 0302 clinical medicine Amputation Traumatic Interneurons medicine Microstimulation Gamma Rhythm Humans Brain Mapping Ventral Thalamic Nuclei business.industry Electroencephalography Signal Processing Computer-Assisted General Medicine Anatomy Somatosensory Cortex medicine.disease body regions 030104 developmental biology Phantom Limb Case-Control Studies Arm Nerve Net business Neuroscience Microelectrodes 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of neurosurgery. 129(4) |
| ISSN: | 1933-0693 |
| Popis: | The amputation of an extremity is commonly followed by phantom sensations that are perceived to originate from the missing limb. The mechanism underlying the generation of these sensations is still not clear although the development of abnormal oscillatory bursting in thalamic neurons may be involved. The theory of thalamocortical dysrhythmia implicates gamma oscillations in phantom pathophysiology although this rhythm has not been previously observed in the phantom limb thalamus. In this study, the authors report the novel observation of widespread 38-Hz gamma oscillatory activity in spike and local field potential recordings obtained from the ventral caudal somatosensory nucleus of the thalamus (Vc) of a phantom limb patient undergoing deep brain stimulation (DBS) surgery. Interestingly, microstimulation near tonically firing cells in the Vc resulted in high-frequency, gamma oscillatory discharges coincident with phantom sensations reported by the patient. Recordings from the somatosensory thalamus of comparator groups (essential tremor and pain) did not reveal the presence of gamma oscillatory activity. |
| Databáze: | OpenAIRE |
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