Role for Mannose Binding Lectin in the Prevention of Mycoplasma Infection
| Autor: | Arine M. Vlieger, A. David B. Webster, Clare Ling, Marina Johnson, Malcolm W. Turner, Angela Wade, Andrea Sherriff, Nigel Klein, R Hamvas |
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| Rok vydání: | 2005 |
| Předmět: |
Immunology
Mannose Mycoplasmataceae medicine.disease_cause Mannose-Binding Lectin Microbiology Exon chemistry.chemical_compound Mycoplasma medicine Humans Mycoplasma Infections Mannan-binding lectin Host Response and Inflammation biology Lectin Flow Cytometry biology.organism_classification Primary and secondary antibodies Infectious Diseases chemistry biology.protein Mollicutes Parasitology |
| Zdroj: | Infection and Immunity. 73:5238-5240 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.73.8.5238-5240.2005 |
| Popis: | Polymorphisms in exon 1 of theMBL-2gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P= 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P= 0.0087). The lectin was shown to bind to three strains of mycoplasma. |
| Databáze: | OpenAIRE |
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