Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli
| Autor: | Elisabeth S. May, Moritz M. Nickel, Markus Ploner, Laura Tiemann, Joachim Gross, Vanessa D. Hohn, Son Ta Dinh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Hot Temperature Brain activity and meditation media_common.quotation_subject Science Pain General Physics and Astronomy Electroencephalography Autonomic Nervous System Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Physical Stimulation Perception Noxious stimulus medicine Gamma Rhythm Humans Pain perception lcsh:Science Evoked Potentials Pain Measurement Multilevel mediation media_common Multidisciplinary medicine.diagnostic_test Motor Cortex Brain Pain Perception General Chemistry ddc 030104 developmental biology Pain psychology Female lcsh:Q Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Pain is a complex phenomenon involving perceptual, motor, and autonomic responses, but how the brain translates noxious stimuli into these different dimensions of pain is unclear. Here, we assessed perceptual, motor, and autonomic responses to brief noxious heat stimuli and recorded brain activity using electroencephalography (EEG) in humans. Multilevel mediation analysis reveals that each pain dimension is subserved by a distinct pattern of EEG responses and, conversely, that each EEG response differentially contributes to the different dimensions of pain. In particular, the translation of noxious stimuli into autonomic and motor responses involved the earliest N1 wave, whereas pain perception was mediated by later N2 and P2 waves. Gamma oscillations mediated motor responses rather than pain perception. These findings represent progress towards a mechanistic understanding of the brain processes translating noxious stimuli into pain and suggest that perceptual, motor, and autonomic dimensions of pain are partially independent rather than serial processes. Pain is a complex phenomenon involving not just the perception of pain, but also autonomic and motor responses. Here, the authors show that these different dimensions of pain are associated with distinct patterns of neural responses to noxious stimuli as measured using EEG. |
| Databáze: | OpenAIRE |
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