Multimarker Assessment of Diastolic Dysfunction in Metabolic Syndrome Patients

Autor: Rodica Rahaian, Anca Daniela Farcaș, Șoimița Suciu, Mihaela Mocan, Florin Petru Anton, S Blaga
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Diastole
Blood Pressure
030209 endocrinology & metabolism
Inflammation
030204 cardiovascular system & hematology
medicine.disease_cause
Sensitivity and Specificity
Ventricular Dysfunction
Left
03 medical and health sciences
Sex Factors
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Natriuretic Peptide
Brain
Internal Medicine
medicine
Humans
Interleukin 6
Aged
Metabolic Syndrome
biology
Interleukin-6
business.industry
Age Factors
Middle Aged
medicine.disease
Peptide Fragments
Hospitalization
Blood pressure
ROC Curve
Echocardiography
Predictive value of tests
Cardiology
biology.protein
Female
Left ventricular diastolic dysfunction
Waist Circumference
medicine.symptom
Metabolic syndrome
business
Biomarkers
Oxidative stress
Zdroj: Metabolic Syndrome and Related Disorders. 15:507-514
ISSN: 1557-8518
1540-4196
2010-2011
Popis: Metabolic syndrome (MetS) has been associated with left ventricular diastolic dysfunction (LVDD) with preserved systolic function. This study aims at identifying the predictive factors for LVDD in MetS patients.The studied group comprised 72 consecutive hospitalized patients (2010-2011) diagnosed with MetS based on AHA/NHLBI/IDF 2009 definition, free of cardiovascular disease (36.11% males, age 59.19 ± 5.26 years), who underwent echocardiographic examination. Laboratory measurements of high-sensitivity C-reactive protein (hs-CRP), fibrinogen (Fbg) and interleukin-6 (IL-6), 8-isoprostaglandin-F2alpa (8-isoPGF2α), uric acid, glutathione peroxidases, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured.LVDD was identified in 47 (65.27%) of the MetS patients. The diastolic blood pressure (DBP) was the strongest prediction factor for LVDD (areas under the receiver operating curve [AUC]: 0.73, odds ratios [OR]: 1.065). The number of MetS criteria was also significantly predictive for LVDD (AUC: 0.65, OR: 2.029, P 0.04). IL-6, hs-CRP, Fbg, and NT-proBNP were predictive for LVDD when receiver operating curve (ROC) analyses were used. The multimarker model comprising age, sex, SBP and DBP, waist, circumference, triglycerides along with hs-CRP, IL-6, and NT-proBNP had the best predictive capacity (AUC: 0.88, P = 0.0001). In multivariate analysis, IL-6 remained an independent predictive biomarker for LVDD (OR: 2.045).Both MetS components and biomarkers of inflammation (IF) are predictive factors for LVDD. The best predictive multimarker model for LVDD in MetS patients is composed of waist, triglycerides (TGL), SBP, DBP, fasting glucose, IL-6, hs-CRP, and NT-proBNP. IL-6 remains an independent predictive biomarker for LVDD in MetS patients, underlining the importance of IF in the evolution of MetS to subclinical cardiac damage.
Databáze: OpenAIRE
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