Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD

Autor:	A. Alvarez-Arcaya, Onofre Combarros, C. Fernandez-Viadero, José Berciano, M. Sanchez-Guerra, Javier Llorca, N. Pena
Rok vydání:	2000
Předmět:	Apolipoprotein E Male Amyloid Genetic Linkage Prions animal diseases Apolipoprotein E4 Locus (genetics) Biology Risk Assessment Prion Proteins White People PRNP chemistry.chemical_compound Apolipoproteins E Alzheimer Disease Genotype medicine Odds Ratio Humans Genetic Predisposition to Disease Allele Age of Onset Protein Precursors Gene Alleles Aged Genetics Aged 80 and over Methionine Polymorphism Genetic Genetic Carrier Screening Homozygote Middle Aged medicine.disease nervous system diseases chemistry Amino Acid Substitution Spain Female Neurology (clinical) Alzheimer's disease
Zdroj:	Neurology. 55(4)
ISSN:	0028-3878
Popis:	Article abstract An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c29e19241970eea0e954f08165a3968 https://pubmed.ncbi.nlm.nih.gov/10953203 Zobrazit plný text záznamu