Mycobacterium marinum infection in fish and man: epidemiology, pathophysiology and management; a review
| Autor: | Ahmed Elsadek, Emad A. Hashish, Huda Kamal, Mahmoud Sitohy, Ali Amer, Abdallah M. A. Merwad, Shimaa A. Elgaml, Ayman Marei |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty animal structures Tuberculosis virulence factors Mycobacterium Infections Nontuberculous Necrotizing granuloma Review Article Microbiology Fish Diseases 03 medical and health sciences Zoonoses parasitic diseases Mycobacterium marinum Infection Epidemiology medicine Animals Humans Pathogen pathophysiology Mycobacterium marinum fish lcsh:Veterinary medicine General Veterinary biology public health Fishes bacterial infections and mycoses biology.organism_classification medicine.disease Pathophysiology 030104 developmental biology mycobacterium marinum lcsh:SF600-1100 Fish epidemiology Water Microbiology |
| Zdroj: | Veterinary Quarterly, Vol 38, Iss 1, Pp 35-46 (2018) The Veterinary Quarterly |
| ISSN: | 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.2018.1447171 |
| Popis: | Mycobacterium marinum is an opportunistic pathogen inducing infection in fresh and marine water fish. This pathogen causes necrotizing granuloma like tuberculosis, morbidity and mortality in fish. The cell wall-associated lipid phthiocerol dimycocerosates, phenolic glycolipids and ESAT-6 secretion system 1 (ESX-1) are the conserved virulence determinant of the organism. Human infections with Mycobacterium marinum hypothetically are classified into four clinical categories (type I–type IV) and have been associated with the exposure of damaged skin to polluted water from fish pools or contacting objects contaminated with infected fish. Fish mycobacteriosis is clinically manifested and characterized in man by purple painless nodules, liable to develop into superficial crusting ulceration with scar formation. Early laboratory diagnosis of M. marinum including histopathology, culture and PCR is essential and critical as the clinical response to antibiotics requires months to be attained. The pathogenicity and virulence determinants of M. marinum need to be thoroughly and comprehensively investigated and understood. In spite of accumulating information on this pathogen, the different relevant data should be compared, connected and globally compiled. This article is reviewing the epidemiology, virulence factors, diagnosis and disease management in fish while casting light on the potential associated public health hazards. |
| Databáze: | OpenAIRE |
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