46, XX gonadal dysgenesis and ovarian hypoplasia
| Autor: | Motlík K, Ladislav Stárka, Eva Šilinková-Málková, Málková J, Chrz R, Kobilková J |
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| Rok vydání: | 1974 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent Gonadal dysgenesis XX gonadal dysgenesis Turner Syndrome Steroid biosynthesis Biology Congenital Abnormalities Gonadal histology Internal medicine Follicular phase Genetics medicine Hydroxyprogesterones Humans Testosterone Ovarian Diseases Genetics (clinical) urogenital system Ovary Androstenedione medicine.disease Hypoplasia Pedigree Endocrinology Female Pure gonadal dysgenesis Maternal Age |
| Zdroj: | Humangenetik. 23(3) |
| ISSN: | 0018-7348 |
| Popis: | 30 patients with the 46,XX gonadal dysgenesis or with a severe primary ovarian hypoplasia are described. In 13 of them the gonadal histology and the patterns of the steroid biosynthesis in vitro are given. The gonads could be divided into three groups: A) “gonadal dysgenesis” without any follicular apparatus, B) “severe ovarian hypoplasy”, C) “hypoplastic sclerocystic ovaries”. Gradual transitions between all these groups and familial occurrence of both hypoplasia and sclerocystic ovaries suggest that certain cases of the ovarian hypoplasia represent a part of the broader spectrum of regressive ovarian condition, appearing as “pure gonadal dysgenesis” in its most severe form. |
| Databáze: | OpenAIRE |
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