Newcastle Disease Virus Inhibits the Proliferation of T Cells Induced by Dendritic Cells In Vitro and In Vivo
| Autor: | Fu Long Nan, Wei Zheng, Wen Long Nan, Tong Yu, Chang Zhan Xie, He Zhang, Xiao Hong Xu, Cheng Hui Li, Zhuo Ha, Jin Yong Zhang, Xin Yu Zhuang, Ji Cheng Han, Wei Wang, Jing Qian, Guan Yu Zhao, Zhuo Xin Li, Jin Ying Ge, Zhi Gao Bu, Ying Zhang, Hui Jun Lu, Ning Yi Jin |
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| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine viruses medicine.medical_treatment T cell Immunology Antigen presentation Newcastle disease virus Priming (immunology) chemical and pharmacologic phenomena proliferation of T cells Biology Major histocompatibility complex Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy dendritic cells Antigen-presenting cell immunosuppression Acquired immune system Cell biology antigen presentation 030104 developmental biology Cytokine medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein lcsh:RC581-607 phenotypic maturation |
| Zdroj: | Frontiers in Immunology, Vol 11 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Newcastle disease virus (NDV) infects poultry and antagonizes host immunity via several mechanisms. Dendritic cells (DCs) are characterized as specialized antigen presenting cells, bridging innate and adaptive immunity and regulating host resistance to viral invasion. However, there is little specific knowledge of the role of DCs in NDV infection. In this study, the representative NDV lentogenic strain LaSota was used to explore whether murine bone marrow derived DCs mature following infection. We examined surface molecule expression and cytokine release from DCs as well as proliferation and activation of T cells in vivo and in vitro in the context of NDV. The results demonstrated that infection with lentogenic strain LaSota induced a phenotypic maturation of immature DCs (imDCs), which actually led to curtailed T cell responses. Upon infection, the phenotypic maturation of DCs was reflected by markedly enhanced MHC and costimulatory molecule expression and secretion of proinflammatory cytokines. Nevertheless, NDV-infected DCs produced the anti-inflammatory cytokine IL-10 and attenuated T cell proliferation, inducing Th2-biased responses. Therefore, our study reveals a novel understanding that DCs are phenotypically mature but dysfunctional in priming T cell responses during NDV infection. |
| Databáze: | OpenAIRE |
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