An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey
| Autor: | Huy Xuan Le, Lan Anh Thi Nguyen, Duong Huy Do, Lay-Myint Yoshida, Xuan Mai Thi Trinh, Minh Nhat Le, Dong Thanh Nguyen, Thu Huong Thi Phan, Hong Vy Nu Ton, Ikumi Sawada, Keisuke Yoshihara, Noriko Kitamura, Koya Ariyoshi, Chien Trong Bui, Hung Thai Do |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Drug Adult Male Adolescent Anti-HIV Agents media_common.quotation_subject Human immunodeficiency virus (HIV) HIV Infections Drug resistance medicine.disease_cause 03 medical and health sciences Young Adult Risk groups high-risk group Drug Resistance Viral HIV Seropositivity antiretroviral drug resistance Seroprevalence Medicine Humans Substance Abuse Intravenous Genotyping Phylogeny media_common Sex Workers business.industry risk behavior virus diseases General Medicine Sequence Analysis DNA Middle Aged Viral Load Virology human immunodeficiency virus (HIV) 030104 developmental biology Infectious Diseases Vietnam Population Surveillance Mutation HIV-1 Female business Viral load Sentinel Surveillance HIV drug resistance |
| Zdroj: | Japanese journal of infectious diseases. 70(6) |
| ISSN: | 1884-2836 |
| Popis: | We studied the prevalence of HIV drug resistance among high-risk groups such as injecting drug users (IDUs), female sex workers (FSWs), and men having sex with men (MSM) in central Vietnam. We used HIV-positive blood samples from 2012?2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays, and the HIV-positive samples were further tested for HIV viral load and drug-resistance mutations (DRMs) by in-house assays. DRMs were identified using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 (high-risk) subjects were screened, and 97 tested positive for HIV infection (IDUs: n = 63, 3.0%; FSWs: n = 24, 0.9%; and MSM: n = 10, 1.0%). Ninety-two of the 97 samples (45 from 2012 and 47 from 2013) were available for further testing. HIV RNA was detected in 56 (60.9%) of the 92 samples, and drug resistance genotyping was successfully performed on 40 (71.4%) samples. All these isolates were subtype CRF01_AE, except for 1 (2.5%) IDU whose HIV belongs to subtype B. Thirteen individuals (32.5%) were carrying HIV with at least 1 DRM: 9 IDUs, 1 FSW, and 3 MSM. Thus, HIV seroprevalence among high-risk individuals in central Vietnam is low, but a high proportion of drug resistant HIV-1 isolates is observed in the high-risk group. Japanese Journal of Infectious Diseases, 70(6), pp.621-627; 2017 |
| Databáze: | OpenAIRE |
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