Amphetamine disrupts negative patterning but does not produce configural association deficits on an alternative task
| Autor: | James R. Blackburn, Stephanie J. Hevenor |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Dextroamphetamine Dose-Response Relationship Drug Increased Dopamine Activity Association Learning Cognition Hippocampal formation Stimulus (physiology) Rats Discrimination Learning Behavioral Neuroscience chemistry.chemical_compound chemistry Dopamine medicine Animals Conditioning Operant Central Nervous System Stimulants Cues Amphetamine Neurotransmitter Psychology Amfetamine Neuroscience medicine.drug |
| Zdroj: | Behavioural brain research. 80(1-2) |
| ISSN: | 0166-4328 |
| Popis: | Three experiments investigated the effects of d-amphetamine on the performance of rats on tasks that required the discrimination of configural cues (i.e., those in which two stimulus elements, tone and light, have a meaning when presented together that is distinct from the meaning of the same elements presented in isolation from each other). In a negative patterning task (Experiment 1), rats were trained in a GO/NO-GO task in which either stimulus alone signalled reward availability whilst the compound did not. Amphetamine (0.5, 1.0 and 2.0 mg/kg) was found to disrupt performance by increasing responses to the unrewarded compound. Responses were also increased during the ITI. In contrast, in Experiments 2 and 3 amphetamine had little impact on performance on a task in which the rats had to respond to either of the single stimuli with one response (lever-press or chain-pull) and to the compound stimulus with the other response. The results add credence to the suggestion of Davidson et al. (Behav. Neurosci., 1993, 107, 227-234) that hippocampal lesions disrupt negative patterning by increasing responsiveness rather than by disrupting a configural association system and do not support the idea that increased dopamine activity disrupts configural associations. The findings are discussed in the context of hippocampal-dopamine interactions. |
| Databáze: | OpenAIRE |
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