Small RNAs Asserting Big Roles in Mycobacteria
| Autor: | Nicolai S. C. van Oers, Przemyslaw Plocinski, Fatma S. Coskun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
sncRNAs
Genetics Small RNA education.field_of_study biology mycobacteria microbiology Population RNA Review QH426-470 biology.organism_classification Biochemistry Mycobacterium tuberculosis Transcriptome RNA processing small RNAs Infectious disease (medical specialty) biochemistry Locked nucleic acid education Molecular Biology Function (biology) |
| Zdroj: | Non-Coding RNA Non-Coding RNA, Vol 7, Iss 69, p 69 (2021) |
| ISSN: | 2311-553X |
| DOI: | 10.3390/ncrna7040069 |
| Popis: | Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), with 10.4 million new cases per year reported in the human population. Recent studies on the Mtb transcriptome have revealed the abundance of noncoding RNAs expressed at various phases of mycobacteria growth, in culture, in infected mammalian cells, and in patients. Among these noncoding RNAs are both small RNAs (sRNAs) between 50 and 350 nts in length and smaller RNAs (sncRNA) < 50 nts. In this review, we provide an up-to-date synopsis of the identification, designation, and function of these Mtb-encoded sRNAs and sncRNAs. The methodological advances including RNA sequencing strategies, small RNA antagonists, and locked nucleic acid sequence-specific RNA probes advancing the studies on these small RNA are described. Initial insights into the regulation of the small RNA expression and putative processing enzymes required for their synthesis and function are discussed. There are many open questions remaining about the biological and pathogenic roles of these small non-coding RNAs, and potential research directions needed to define the role of these mycobacterial noncoding RNAs are summarized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |